• ISSN(Print): 2789-4355
    ISSN(Online): 2958-0358
  • editor.hmdj@hitec-ims.edu.pk
    051- 4908582
  • HITEC-IMS, HIT, Taxila Cantt,
    Punjab, Pakistan
  • Submit Manuscript
Compliance to Antihypertensive Treatment Among Hypertensive Patients at a Tertiary Care Hospital

Authors

Ghulam Mustafa
Associate Professor, Department of community Medicine
Muhammad Zafar Majeed
Associate Professor, Department of Medicine
Manzur Ahmed Manzur
Associate Professor, Department of Medicine, Sheikh Zayed Medical College/Hospital, Rahim Yar Khan

Keywords

Antihypertensive agents, Compliance, Hypertension.

Abstract

Objective:
: To assess the compliance of hypertensive patients to the treatment prescribed by the physician.
Study Design:
Cross-Sectional Study.
Place and Duration of Study:
Sheikh Zayed Medical College, Rahim Yar Khan, 01 month ( June to July 2023).
Methodology:
All patients who presented to the medical outpatients department from June to July 2023 and fulfilled the inclusion criteria were inducted in the study. Predesigned questionnaires were used for data collection. The study subjects were hypertensive patients who attended the outpatient department of the Medical unit of the hospital. The subjects included were at least 20 years old and using antihypertensive drugs for at least 6 months. The non-probability, convenience sampling technique was used for sample collection. The questionnaire included information regarding the sociodemographic status of the participants and questions that assessed compliance to antihypertensive therapy. Data were collected, and analyzed by using SPSS version 23.
Results:
: Total 190 hypertensive patients were included in the study. Out of 190 study subjects, 88 (46.31%) were found to be compliant to their antihypertensive drug treatment, while 102 (53.69%) were non-compliant. The high cost of the medicines (p=0.04) and forgetfulness (p=0.05) significantly predicted noncompliance to antihypertensive treatmen.
Conclusion:
The level of compliance to antihypertensive medication was poor in more than half of the hypertensive patients. The significant predictors of non-compliance were forgetfulness and the high cost of medicine.

How to cite this article

Mustafa G, Majeed MZ, Manzur MA. Compliance to Antihypertensive Treatment among Hypertensive Patients at a Tertiary Care Hospital. HMDJ. 2024 Dec; 04(02): 50-54. https://doi.org/10.69884/hmdj.4.2.9012.
DOI: https://doi.org/10.69884/hmdj.4.2.9012

References

  1. Shah N, Shah Q, Shah AJ. The burden and high prevalence of hypertension in Pakistani adolescents: a meta-analysis of the published studies. Arch Public Health. 2018 Apr;76:20. https://doi.org/10.1186/s13690-018-0265-5.
  2. World Health Organization. Hypertension {Updated 2023 March 16}.Available from: https://www.who.int/news-room/fact-sheets/detail/hypertension.
  3. Mutneja E, Yadav R, Dey AB, Gupta P. Frequency and predictors of compliance among patients taking antihypertensive medicines. Indian Heart J. 2020 Mar-Apr;72(2):136-139. https://doi.org/10.1016/j.ihj.2020.03.008.
  4. Mahmood S, Jalal Z, Hadi MA, Khan TM, Haque MS, Shah KU. Prevalence of non-adherence to antihypertensive medication in Asia: a systematic review and meta-analysis. Int J Clin Pharm . 2021 Jun;43:486–501. https://doi.org/10.1007/s11096-021-01236-z.
  5. Liaqat S, Afzal K, Ali A, Arif U, Parveen S. Prevalence of non-compliance to prescribed antihypertensive medication among hypertensive middleaged adults at a tertiary care hospital, Faisalabad, Pakistan: a descriptive cross-sectional study. J Uni Med Dent Coll.2024 Oct-Dec;15(4): 912-920.https://doi.org/10.37723/jumdc.v15i4.1048.
  6. Mahmood S, Jalal Z, Hadi MA, Orooj H, Shah KU. Non-adherenceto prescribed antihypertensives in primary, secondary and tertiary healthcare settings in Islamabad, Pakistan: a cross-sectional study. Patient Prefer Adherence. 2020 Jan;14:73-85.https://doi.org/10.2147/PPA.S235517.
  7. Hydr AA, Morrow RH. Applying burden of disease methods in developing countries: a case study from Pakistan. Am J Public Health. 2000 Apr;90:1235–1212. https://doi.org/10.2105/ajph.90.8.1235.
  8. Alam A, Amanullah F, Baig-Ansari N, Lotia-Farrukh I, Khan FS. Prevalence and risk factors of kidney disease in urban Karachi: baseline findings from a community cohort study. BMC Res Notes. 2014 Mar 27;7:179-190. https://doi.org/10.1186/1756-0500-7-179.
  9. Jessani S, Bux R, Jafar TH. Prevalence, determinants, and management of chronic kidney disease in Karachi, Pakistan - a community based cross-sectional study. BMC Nephrol. 2014; 15:90-99. htttps://doi.org/10.1186/1471-2369-15-90.
  10. Irazola VE, Gutierrez L, Bloomfield G, Carrillo-Larco RM, Prabhakaran D, Gaziano T, et al. Hypertenesion prevalence, awareness, treatment, and control in selected LMIC communities: Results From the NHLBI/UHG network of centers of excellence for chronic diseases. Glob Heart. 2016 Mar;11(1):47–59. http://dx.doi.org/10.1016/ j.gheart.2015.12.008.
  11. Cherney K. Complications of Hypertension . Healthline; 2024 May 8. Available from: https://www. https://www.healthline.com/health/highblood-pressure-hypertension/hypertension-complications.
  12. Li AL, Ji Y, Zhu S, Hu ZH, Xu XJ, Wang YW, et al. Risk probability and influencing factors of stroke in followed-up hypertension patients. BMC Cardiovasc Disord.2022 Jul 24; 22 :328-337. https://doi.org/10.1186/s12872-022-02780-w
  13. Shafi ST, Shafi T. A survey of hypertension prevalence, awareness, treatment, and control in health screening camps of rural central Punjab, Pakistan. J Epidemiol Glob Health. 2017 Jun;7(2):135–140. https://doi.org/10.1016/j.jegh.2017.01.001.
  14. Ho PM, Bryson CL, Rumsfeld JS. Medication adherence: its importance in cardiovascular outcomes. Circulation. 2009 Jun;119(23):3028-3035. https://doi.org/10.1161/CIRCULATIONAHA.108.768986.
  15. Tajeu GS, Kent ST, Huang L, Bress AP, Cuffee Y, Halpern MT,et al. Antihypertensive medication nonpersistence and low adherence foradults less than 65 years initiating treatment in 2007-2014. Hypertension. 2019 Jul;74(1):35–46. https://doi.org/10.1161/HYPERTENSIONAHA.118.12495.
  16. Tajeu GS, Kent ST, Kronish IM, Huang L, Krousel-Wood M, Bress AP, et al. Trends in antihypertensive medication discontinuation and low adherence among Medicare beneficiaries initiating treatment from 2007 to 2012.Hypertension. 2016 Sep; 68(3):565–575. https://doi.org/10.1161/HYPERTENSIONAHA.116.07720.
  17. Algabbani, FM, Algabbani AM. Treatment adherence among patients with hypertension: findings from a cross-sectional study. Clin Hypertens.2020 Sep 15;26:18 -27. https://doi.org/10.1186/s40885-020-00151-1
  18. Burnier M. Drug adherence in hypertension. Pharmacol Res. 2017 Jan;125:142-149. http://dx.doi.org/10.1016/j.phrs.2017.08.015.
  19. Zhang NJ, Terry A, McHorney CA. Impact of health literacy on medication adherence: a systematic review and meta-analysis. Ann Pharmacother. 2014 Jun; 48:741–751. https://doi.org/10.1177/1060028014526562.
  20. Jung O, Gechter JL, Wunder C, Paulke A, Bartel C, Geiger H, et al. Resistant hypertension? Assessment of adherence by toxicological urine analysis. J Hypertens. 2013 Apr; 31(4):766–774. https://doi.org/10.1097/HJH.0b013e32835e2286.
  21. Busari OA, Olusegun T, Olanrewaju TO, Desalu OO, Opadijo OG , Jimoh AK, et al. Impact of patients’ knowledge, attitude and practices on hypertension on compliance with antihypertensive drugs in a resourcepoor setting. TAF Preventive Medicine Bulletin. 2010;9(2):87-92. Available at https://api.semanticscholar.org/ CorpusID:71073730.
  22. Yousuf FS, Khan MA, Bibi R, Arif A, Arshad A, Almas A. Medication adherence in patients with uncontrolled hypertension & hypertensive crisis presenting to a hospital setting in karachi, pakistan. Cureus. 2023 Jan.20;15(1):e33995. https://doi.org/10.1097/01.hjh.0000940164.93230.0d.
  23. Asgedom SW, Atey TM, Desse TA. Antihypertensive medication adherence and associated factors among adult hypertensive patients at Jimma University Specialized Hospital, southwest Ethiopia. BMC Res Notes. 2018 Jan15;11(1):27- 35 Erratum in: BMC Res Notes. 2018 Aug 16;11(1):592. https://doi.org/10.1186/s13104-018-3139-6.
  24. Mekonnen HS, Gebrie MH, Eyasu KH, Gelagay AA. Drug adherence for antihypertensive medications and its determinants among adult hypertensive patients attending in chronic clinics of referral hospitals in Northwest Ethiopia. BMC Pharmacol Toxicol. 2017 Apr 5;18(1):27-36. https://doi.org/10.1186/s40360-017-0134-9.