• ISSN(Print): 2789-4355
    ISSN(Online): 2958-0358
  • editor.hmdj@hitec-ims.edu.pk
    051- 4908582
  • HITEC-IMS, HIT, Taxila Cantt,
    Punjab, Pakistan
  • Submit Manuscript
HITEC Medical & Dental Journal (HMDJ) Submit Manuscript
SERUM VITAMIN D, CALCIUM AND PHOSPHATE LEVELS IN PATIENTS WITH ACUTE MANIA: A CROSS-SECTIONAL COMPARATIVE STUDY

Authors

Ather Muneer
Associate professor of Psychiatry, HBS Medical and Dental College, Islamabad
Nargis Muneer
Clinical lecturer, Behavioral Sciences, Rawal Institute of Behavioral Sciences, Islamabad
Mahwish Ahmad
Assistant professor of Medicine, HBS Medical and Dental College, Islamabad
Zara Inam
Final year MBBS, Rawal Institute of Health Sciences, Islamabad

Abstract

Objectives To investigate the levels of serum Vitamin D, Calcium and Phosphate levels in the manic phase of bipolar disorder.
Study Design: Cross-sectional study with comparative groups.
Place and duration of Study: Rawal General Hospital, Islamabad, 10 months (October 2023 to Jul 2024).
Methodology: Forty patients suffering from manic episode according to the Diagnostic and Statistical Manual of Mental Disorders(DSM)- 5 criteria were included in the study, after informed consent. They were compared to 40 age and gender-matched healthy controls who had no previous psychiatric history. The authorization to conduct the study was given by the Ethical Review Board of the medical college vide the ERB permission letter. Young Mania Rating scale was administered to the patients to assess the severity of mania. Venous blood was drawn from all the participants to determine the serum levels of vitamin D, Calcium and Phosphate. Statistical analysis was done with the help of SPSS-23. For numeric variables, descriptive statistics and mean with standard deviation were calculated, whereas frequencies and percentages were calculated for the categorical variables. For the analysis of categorical variables Chi-square test was used, and for the numerical variables, the Independent samples t-test was utilized. The p- value < 0.05 was considered significant.
Results: With respect to demographic details, the cases and controls were homogeneous. The mean Serum vitamin D was 11.52 ± 5.83 ng/ml for the cases and 17.46 ± 6.18 ng/ml for the controls, and this result was statistically significant(P < 0.01).
Conclusion: In our sample, bipolar patients with a manic episode had significantly lower Vitamin D levels, and this purportedly implicated the latter factor in the pathogenesis of bipolar mania.
Keywords: Bipolar disorder, Inflammation, Mania, Vitamin D.

How to cite this article

Muneer A, Muneer N, Ahmad M, Inam Z. Serum Vitamin D, Calcium and Phosphate levels in patients with acute mania: A Cross-Sectional comparative study. HMDJ. 2025 June; 05(01): 26-30.
DOI: https://doi.org/10.69884/hmdj.5.1.3699

References

  1. Haggarty SJ, Karmacharya R, Perlis RH. Advances toward precision medicine for bipolar disorder: mechanisms & molecules. Mol Psychiatry 2021; 26(1): 168-185. doi: https://doi.org/10.1038/s41380-020-0831-4.
  2. McIntyre RS, Berk M, Brietzke E, Goldstein BI, López-Jaramillo C, Kessing LV, et al. Bipolar disorders. Lancet 2020; 396(10265): 1841-1856. doi: https://doi.org/10.1016/S0140-6736(20)31544-0.
  3. Jones GH, Vecera CM, Pinjari OF, Machado-Vieira R. Inflammatory signaling mechanisms in bipolar disorder. J Biomed Sci 2021;28(1):4566; doi: https://doi.org/10.1186/S12929-021-00742-6.
  4. Kouba BR, Camargo A, Gil-Mohapel J, Rodrigues ALS. Molecular Basis Underlying the Therapeutic Potential of Vitamin D for the Treatment of Depression and Anxiety. Int J Mol Sci. 2022 Jun 25;23(13):7077. doi: https://doi.org/10.3390/ijms23137077..
  5. Benedetti F, Aggio V, Pratesi ML, Greco G, Furlan R. Neuroinflammation in Bipolar Depression. Front Psychiatry. 2020 Feb 26;11:71. doi: https://doi.org/10.3389/fpsyt.2020.00071.
  6. İmre O, Karaağaç M, Caglayan C. Does Decreased Vitamin D Level Trigger Bipolar Manic Attacks? Behav Sci (Basel). 2023 Sep 18;13(9):779. doi: https://doi.org/10.3390/bs13090779.
  7. Ciobanu AM, Petrescu C, Anghele C, Manea MC, Ciobanu CA, Petrescu DM, et al. Severe Vitamin D Deficiency-A Possible Cause of Resistance to Treatment in Psychiatric Pathology. Medicina (Kaunas) 2023; 59(12): 2056. doi: https://doi.org/10.3390/medicina59122056.
  8. Grudet C, Wolkowitz OM, Mellon SH, Malm J, Reus VI, Brundin L, Nier BM, Dhabhar FS, Hough CM, Westrin Å, Lindqvist D. Vitamin D and inflammation in major depressive disorder. J Affect Disord. 2020 Apr 15;267:33-41. doi: https://doi.org/10.1016/j.jad.2020.01.168.
  9. Patrick RP, Ames BN. Vitamin D and the omega-3 fatty acids control serotonin synthesis and action, part 2: relevance for ADHD, bipolar disorder, schizophrenia, and impulsive behavior. FASEB J. 2015 Jun;29(6):2207-22. doi: https://doi.org/10.1096/fj.14-268342.
  10. Cereda G, Enrico P, Ciappolino V, Delvecchio G, Brambilla P. The role of vitamin D in bipolar disorder: Epidemiology and influence on disease activity. J Affect Disord. 2021 Jan 1;278:209-217. doi: https://doi.org/10.1016/j.jad.2020.09.039.
  11. In J, Kang H, Kim JH, Kim TK, Ahn EJ, Lee DK, et al. Tips for troublesome sample-size calculation. Korean J Anesthesiol. 2020 Apr;73(2):114120. doi: 10.4097/kja.19497. Epub 2020 Mar 16. Erratum in: Korean J Anesthesiol. 2020 Jun;73(3):268. doi: https://doi.org/10.4097/kja.19497.e1.
  12. Marazziti D, Gurrieri R, Mucci F. Vitamin D, vitamin B12, folate, homocysteine, and major haemato-chemical parameters in patients with mood disorders. Eur Psychiatry. 2024 Aug 27;67(Suppl 1):S673. doi: https://doi.org/10.1192/j.eurpsy.2024.1399.
  13. Khan N, Nasar A, Bajwa S, Jawad Butt A, Azher A, Mushtaq T, et al. TULIP study: Trail of Lurasidone in bipolar disorder in Pakistan. Saudi J Biol Sci. 2021 Jan;28(1):1128-1132. doi: https://doi.org/10.1016/j.sjbs.2020.11.044.
  14. Lavigne JE, Gibbons JB. The association between vitamin D serum levels, supplementation, and suicide attempts and intentional self-harm. PLoS One. 2023 Feb 1;18(2):e0279166. doi: https://doi.org/10.1371/journal.pone.0279166.
  15. Späth Z, Tmava-Berisha A, Fellendorf FT, Stross T, Maget A, Platzer M, et al. Vitamin D Status in Bipolar Disorder. Nutrients. 2023 Nov 11;15(22):4752. doi: https://doi.org/10.3390/nu15224752.
  16. Wassif GA, Alrehely MS, Alharbi DM, Aljohani AA. The Impact of Vitamin D on Neuropsychiatric Disorders. Cureus. 2023 Oct 26;15(10):e47716. doi: https://doi.org/10.7759/cureus.47716.
  17. AlGhamdi SA. Effectiveness of Vitamin D on Neurological and Mental Disorders. Diseases. 2024 Jun 20;12(6):131. doi: https://doi.org/10.3390/diseases12060131.
  18. Zheng X, Neeraj D, Zhu Q, Zhang Y, Li T, Yang W, et al. Latent profile analysis of vitamin D and its association with depression severity of hospitalized patients with bipolar depression. Nutr Neurosci. 2024 Dec;27(12):14131421.doi: https://doi.org/10.1080/1028415X.2024.2339739.
  19. Arya S, Kamyab A, Sanatkar SA, Pourmehdiardebili M, Ebrahimi A, Kamyab P,et al. Evaluating the association of vitamin D3, parathyroid hormone, and C-reactive protein serum levels in patients with an acute psychotic episode: a cross-sectional study in tertiary centre in Iran. BMC Psychiatry. 2023 Oct 6;23(1):724. doi: https://doi.org/10.1186/s12888023-05234-5.
  20. Roy NM, Al-Harthi L, Sampat N, Al-Mujaini R, Mahadevan S, Al Adawi S,et al. Impact of vitamin D on neurocognitive function in dementia, depression, schizophrenia and ADHD. Front Biosci (Landmark Ed). 2021 Jan 1;26(3):566-611. doi: https://doi.org/10.2741/4908.
  21. Jahan-Mihan A, Stevens P, Medero-Alfonso S, Brace G, Overby LK, Berg K,et al. The Role of Water-Soluble Vitamins and Vitamin D in Prevention and Treatment of Depression and Seasonal Affective Disorder in Adults. Nutrients. 2024 Jun 17;16(12):1902. doi: https://doi.org/10.3390/nu16121902.

All Volumes

HMDJ © All Right Reserved || Powered By IT Department