SERUM VITAMIN D, CALCIUM AND PHOSPHATE LEVELS IN PATIENTS WITH ACUTE MANIA: A CROSS-SECTIONAL COMPARATIVE STUDY

Abstract

Objective: To investigate the levels of serum Vitamin D, Calcium and Phosphate levels in the manic phase of bipolar disorder.
Study Design: Cross-sectional study with comparative groups.
Place and Duration of Study: Rawal General Hospital, Islamabad, 10 months (October 2023 to Jul 2024).
Methodology: Forty patients suffering from manic episode according to the Diagnostic and Statistical Manual of Mental
Disorders(DSM)- 5 criteria were included in the study, after informed consent. They were compared to 40 age and gender-matched
healthy controls who had no previous psychiatric history. The authorization to conduct the study was given by the Ethical Review
Board of the medical college vide the ERB permission letter. Young Mania Rating scale was administered to the patients to assess
the severity of mania. Venous blood was drawn from all the participants to determine the serum levels of vitamin D, Calcium
and Phosphate. Statistical analysis was done with the help of SPSS-23. For numeric variables, descriptive statistics and mean with
standard deviation were calculated, whereas frequencies and percentages were calculated for the categorical variables. For the
analysis of categorical variables Chi-square test was used, and for the numerical variables, the Independent samples t-test was
utilized. The p- value < 0.05 was considered significant.
Results: With respect to demographic details, the cases and controls were homogeneous. The mean Serum vitamin D was 11.52 ±
5.83 ng/ml for the cases and 17.46 ± 6.18 ng/ml for the controls, and this result was statistically significant(P < 0.01).
Conclusion: In our sample, bipolar patients with a manic episode had significantly lower Vitamin D levels, and this purportedly
implicated the latter factor in the pathogenesis of bipolar mania.
Keywords: Bipolar disorder, Inflammation, Mania, Vitamin D.
How to cite this article: Muneer A, Muneer N, Ahmad M, Inam Z. Serum Vitamin D, Calcium and Phosphate levels in patients with
acute mania: A Cross-Sectional comparative study. HMDJ. 2025 June; 05(01): 26-30. https://doi.org/10.69884/hmdj.5.1.3699