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Development Of A PIMS Specific Dengue Hepatitis Severity Score: A Retrospective Cross Sectional Study Of EMR Data

Authors

Shaista Faheem
Associate Professor, Pakistan Institute of Medical Sciences (PIMS), Islamabad, Pakistan
Sana Waqar
Postgraduate Trainee, Pakistan Institute of Medical Sciences (PIMS), Islamabad, Pakistan
Fareha Rasheed
Postgraduate Trainee, Pakistan Institute of Medical Sciences (PIMS), Islamabad, Pakistan
Maria Zafar
Assistant Professor Medicine, Pakistan Institute of Medical Sciences (PIMS), Islamabad, Pakistan
Samina Rashid
Consultant Physician, Military Hospital, Rawalpindi, Pakistan
Aashar Khalid
House Officer Medicine, Pakistan Institute of Medical Sciences (PIMS), Islamabad, Pakistan

Abstract

Objective:
To develop and evaluate a simple PIMS-specific Dengue Hepatitis Severity Score using routinely available clinical variables.
Study Design:
Retrospective cross-sectional study.
Place and Duration of Study:
Pakistan Institute of Medical Sciences (PIMS), Islamabad, 06 months (June to November 2025).
Patients and Methods:
This study was conducted using electronic medical records( EMR) of patients of ≥13 years of age, with lab-confirmed dengue infection and hepatic involvement. The patients were categorized into severe and non-severe dengue hepatitis groups. Independent predictors were identified using multivariate logistic regression, and a clinical severity score was developed. Receiver operating characteristic (ROC) curve analysis was used to evaluate diagnostic performance.
Results:
Total patients in this study were 97. Bleeding (OR = 11.24), hypotension (OR = 6.99), and hepatomegaly (OR = 5.95) were independent predictors of severe dengue hepatitis (p < 0.05). A three-point severity score was constructed (0–3). The score demonstrated good discrimination with an AUC of 0.761 (95% CI: 0.659–0.863). A cut-off ≥1 showed sensitivity of 77.1% and specificity of 71.0%.
Conclusion:
The PIMS Dengue Hepatitis Severity Score is a simple, bedside tool that effectively identifies patients at risk of severe disease. It can be helpful for early triage and clinical decision-making, although external validation is required before general use.
Kewords:
Dengue, Hepatitis, Risk Assessment, Severity of Illness Index

How to cite this article

Faheem S, Waqar S, Rasheed F, Zafar M, Rashid S, Khalid A. Development of a PIMS Specific Dengue Hepatitis Severity Score: A Retrospective Cross Sectional Study of EMR Data. HMDJ. 2026 June; 06(01): 60-65.
DOI: https://doi.org/10.69884/hmdj.6.1.1789

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