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Efficacy Of Vaginal Misoprostol In The Treatment Of Missed Miscarriage Before 24 Weeks Of Gestation

Authors

Maha Khan
Senior Registrar Gynae/Obs, Swat Medical College and Teaching Hospital, Swat
Romana Bibi
Senior Registrar Gynae/Obs, Swat Medical College and Teaching Hospital, Swat
Asma Hameed
Senior Registrar Gynae/Obs, Swat Medical College and Teaching Hospital, Swat
Muhammad Awais
Medical Officer, Swat Medical College and Teaching Hospital, Swat
Mehwish Khan
Demonstrator DME, Swat Medical College and Teaching Hospital, Swat
Ammara Khan
JR Radiology, Swat Medical College and Teaching Hospital, Swat

Abstract

Objective:
To determine the efficacy of vaginal misoprostol in the treatment of missed miscarriage in less than 24 weeks of gestation.
Study Design:
Cross-sectional study.
Place and Duration of Study:
Department of Obstetrics & Gynecology, Swat Medical Complex, Swat, 06 months (August 2025 to February 2026).
Patients and Methods:
This study was conducted on 194 patients, aged 18 to 40 years, with miscarriage of < 24 weeks of gestation. We determined the efficacy of vaginal misoprostol in the treatment of missed miscarriage. The dosage of vaginal misoprostol was adjusted according to the period of gestation and administered in compliance with the International Federation of Gynecology and Obstetrics (FIGO)-recommended protocol for pregnancy termination.
Results:
The mean age of the patients was 29.03±6.66 years. The mean gestational age was 16.89±3.19 weeks. 68% patients had parity 0-3, while 32% patients had parity > 3. The efficacy of misoprostol in our study was 93 (47.9%) with =value 0.05. A greater proportion of successful outcomes was observed in patients with a gestational age of less than 18 weeks (63.4%) compared with those at 18–24 weeks of gestation (36.6%); however, it did not reach statistical significance (p = 0.38).
Conclusion:
Vaginal Misoprostol in the treatment of missed miscarriage in less than 24 weeks of gestation was effective in terms of non-surgical complete evacuation of the conception product.
Kewords:
Gestational age, miscarriage, misoprostol, pregnancy, termination of pregnancy.

How to cite this article

Khan M, Bibi R, Hameed A, Awais M, Khan M, Khan A. Efficacy of Vaginal Misoprostol in the Treatment of Missed Miscarriage before 24 weeks of Gestation. HMDJ. 2026 June; 06(01): 08-12.
DOI: https://doi.org/10.69884/hmdj.6.1.3294

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