Efficacy of Misoprostol in the Treatment of Missed Miscarriage in less than 24 weeks of Gestation

Abstract

INTRODUCTION: The evacuation of the fetus before the viability age or before the end of the 24^th week is termed an abortion or miscarriage.  The fetus is deemed viable after the 24^th week of pregnancy. Consequently, there is a need for an inexpensive and effective alternative agent. The goal of this research is to determine the efficacy of misoprostol in patients with missed miscarriage before 24 weeks of gestation.

OBJECTIVE: To determine the efficacy of misoprostol in the treatment of missed miscarriage in less than 24 weeks of gestation.

METHODOLGY: A cross-sectional study was conducted in the department of Obstetrics & Gynecology department, Swat Medical Complex swat, from August 2025 to February 2026. We conducted this study on 194 patients aged 18 to 40 years with miscarriage less than 24 weeks of gestation. We determined the efficacy of misoprostol in the treatment of missed miscarriage.

RESULTS:

The mean age of the patients was 29.03±6.66 years. Mean gestational age was 16.89±3.19 weeks. 68% patients had parity 0-3, while 32% patients had parity > 3. The efficacy of misoprostol in our study was 93 (47.9%) with p=value 0.05. Misoprostol was more effective in patients having a period of gestation less than 18 weeks (63.4%) and those having 18-24 weeks (36.6%).

CONCLUSION:

We conclude that misoprostol in the treatment of missed miscarriage in less than 24 weeks of gestation was effective in 93 (47.9%) patients in terms of non-surgical complete evacuation of the conception product.

KEYWORDS: Missed miscarriage, gestational age, misoprostol, pregnancy

KEYWORDS: Missed miscarriage, gestational age, misoprostol, pregnancy